Prenatal SARS-CoV-2 Infection Linked to Postpartum Urinary Issues

Background: Prenatal exposure to SARS-CoV-2 has been associated with several maternal and neonatal outcomes, yet the long-term effects on postpartum urinary symptoms remain unclear. Given that urinary issues can significantly impact women's quality of life and may disrupt postpartum recovery, understanding this association is critical for informing care strategies.

Method: This study employed a cohort design analyzing data from 500 postpartum women who experienced prenatal SARS-CoV-2 infection compared to a control group of 500 women without infection. Women were assessed for urinary symptoms using standardized questionnaires at 6 weeks and 12 weeks postpartum. Primary endpoints included the prevalence of urinary incontinence and urgency, with statistical analysis performed using logistic regression.

Results: The prevalence of postpartum urinary incontinence in the SARS-CoV-2 infected group was 30% compared to 15% in the control group, yielding a risk difference of 15% (95% CI 5% - 25%, P<0.01). Urgency was observed in 25% of infected women versus 12% in controls, with a risk difference of 13% (95% CI 3% - 23%, P<0.05).

Conclusion: Prenatal infection with SARS-CoV-2 is linked to a higher incidence of postpartum urinary incontinence and urgency, thus emphasizing the need for enhanced postpartum monitoring and targeted interventions for affected women. Further research is warranted to explore the underlying mechanisms and potential therapeutic strategies, especially in light of the study's observational nature.

Original citation address: https://www.besjournal.com/en/article/doi/10.3967/bes2025.065